IRRITABLE BOWEL SYNDROME Sex specific alterations in autonomic function among patients with irritable bowel syndrome

نویسندگان

  • K Tillisch
  • E A Mayer
  • J S Labus
  • J Stains
  • L Chang
  • B D Naliboff
چکیده

Background: Irritable bowel syndrome (IBS) is associated with increased psychological symptoms, early life stressors, and alterations in visceral perception and brain responses to noxious visceral stimuli. The autonomic nervous system (ANS) is a likely mediator for these brain-gut interactions. The few studies directly examining ANS measures have been suggestive of alterations in some IBS patients, but no studies to date have examined the potentially critical variables of sex differences or response to visceral stimulation. Aims: (1) To test differences in ANS function during rest and during a visceral stressor (rectosigmoid balloon distension) between IBS patients and healthy control subjects. (2) To examine the role of sex on the autonomic responses of IBS patients. Methods: Baseline autonomic measures were evaluated from 130 Rome I positive IBS patients and 55 healthy control subjects. Data were also collected from a subset of 46 IBS patients and 16 healthy control subjects during a sigmoid balloon distension study. Heart rate variability measures of peak power ratio (PPR) and peak power high frequency (PPHF) were analysed to assess sympathetic balance and parasympathetic response, respectively. Peripheral sympathetic response was measured by skin conductance. Results: IBS patients showed a greater skin conductance response to visceral distension than controls. IBS patients had higher PPR and lower PPHF across conditions. Male IBS patients had higher skin conductance and PPR than females and lower PPHF. Conclusions: IBS patients have altered autonomic responsiveness to a visceral stressor, with increased sympathetic and decreased parasympathetic activity. These differences are predominantly seen in males.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A review on pathophysiology of irritable bowel syndrome with emphasis on the role of brain factors

Irritable bowel syndrome (IBS) is a common and chronic functional gastrointestinal disorder that causes a great burden on the individual and society. Despite many studies, there is no consent about the etiology, diagnostic and treatment method of IBS. In recent years, neurologic factors have been given attention for better understanding and management of this disorder. The aim of the present st...

متن کامل

Prevalence of Celiac Disease in Patients with Irritable Bowel Syndrome in Kerman, Iran

Background & Aims: Celiac disease or gluten-sensitive enteropathy is a relatively uncommon digestive disease. Moreover, irritable bowel syndrome (IBS) is a common functional bowel disorder. Some IBS patients have celiac disease, with similar IBS symptoms in addition to some serious complications. The only possible treatment for this condition is changing the patients diet (gluten free diet). Gi...

متن کامل

Comparing the mental health of patients with irritable bowel syndrome and healthy subjects in Rasht (Iran), 2014-2015

Background and Objective: Irritable bowel syndrome is one of the most common functional gastrointestinal disorders in which psychological factors play an important role in developing and exacerbating the symptoms. The aim of current study was comparing mental health of patients with irritable bowel syndrome with normal individuals alongside the role of mental health predicting high risk of irri...

متن کامل

THE COMPARISON OF MENTAL PATHOLOGY DIMENSIONS OF PATIENTS WITH IRRITABLE BOWEL SYNDROME WITH NON-DIABETIC PATIENTS IN GASTROENTEROLOGY CLINICS OF TEHRAN

Background & Aims: Irritable bowel syndrome is a common chronic disease that up to 20% of patients are referred to gastroenterologists. The aim of this study was to investigate the psychopathology of people with irritable bowel syndrome and non-infected individuals. Materials & Method: The present study was a comparative-comparative study. The statistical population included all patients that c...

متن کامل

The Effectiveness of Acceptance and Commitment-Based Therapy on the Immune Function and Activity Limitations in Patients With Irritable Bowel Syndrome

Introduction: Irritable bowel syndrome is the most common, costly, and disabling dysfunction of the gastrointestinal tract. Mental disorders can be one of the main factors in the onset, continuation, or exacerbation of gastrointestinal signs and symptoms in people with this syndrome. Commitment and acceptance therapy is a mixture of four approaches of awareness, acceptance, commitment, and beha...

متن کامل

The Relationship between Stressful Life Events, Type D Personality, Catastrophizing and Psychological Distress on Severity of Symptom in Patients with Irritable Bowel Syndrome

Introduction: The purpose of this study was to investigate the relationship between stressful life events-type personality, catastrophizing and psychological distress with symptoms severity in patients with Irritable Bowel Syndrome. Methods: This research was a correlational study and the population were consisted of patients with Irritable Bowel Syndrome in Isfahan who were diagnosed with Irr...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005